Comparison of Bone Mineral Density and Area of Newly Formed Bone Around Ti-15%Zr-4%Nb-4%Ta Alloy and Ti-6%Al-4%V Alloy Implants

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  • Nakada Hiroshi
    Department of Gnatho-Oral Prosthetic Rehabilitation, Nihon University School of Dentistry at Matsudo
  • Numata Yasuko
    Nihon University Graduate School of Dentistry at Matsudo, Complete Denture Prosthodontics
  • Sakae Toshiro
    Department of Histology, Cytology and Developmental Anatomy, Nihon University School of Dentistry at Matsudo
  • Okazaki Yoshimitsu
    Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology
  • Tanimoto Yasuhiro
    Department of Dental Biomaterials, Nihon University School of Dentistry at Matsudo
  • Tamaki Hiroyuki
    Department of Oral and Maxillofacial Implantology, Nihon University School of Dentistry at Matsudo
  • Katou Takao
    Department of Oral and Maxillofacial Implantology, Nihon University School of Dentistry at Matsudo
  • Ookubo Atsushi
    Department of Histology, Cytology and Developmental Anatomy, Nihon University School of Dentistry at Matsudo
  • Kobayashi Kihei
    Nihon University Research Center
  • Z. LeGeros Racquel
    Department of Biomaterials and Biomimetics, New York University College of Dentistry

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Abstract

A newly developed titanium alloy, Ti-15%Zr-4%Nb-4%Ta (Ti15Zr4Nb4Ta), has been shown to have excellent mechanical characteristics, corrosion fatigue strength, anticorrosion, cytocompatibility, and biocompatibility. The purpose of this study was to compare the bone mineral density (BMD) and area of newly formed bone around Ti15Zr4Nb4Ta implants to that around Ti-6%Al-4%V alloy (Ti6Al4V) implants. We inserted 2 types of implants (surface treat of the machine and the blast implant) in New Zealand white rabbit femurs under general anesthesia. The rabbit was done perfusion fixation of 4, 8, 16, 24, and 48 weeks later, and the femurs with the implants were collected and we observed the surrounding bone by an implant drawing test. We measured the BMD and the area of the newly formed bone surrounding the implant inserted part using image analysis software Image-Pro PLUS Ver. 4.0® which it developed newly in micro focus computed tomography (micro CT). The results showed the machine and the blast implant together, which the BMD and area around the Ti15Zr4Nb4Ta implants were comparable to or greater than those around the Ti6Al4V implants. These results suggested that the new alloy, Ti15Zr4Nb4Ta, might be useful for orthopedic or dental implants with the added advantage of superior biologic safety and mechanical properties than the current alloy, Ti6Al4V.

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