Expression of Wnt Signaling Pathway Components in RA-induced Cleft Palate Mouse
-
- Wang Ru
- Department of Dentistry, the First Affiliated Hospital of Dalian Medical University
-
- Cong Wei
- Department of Oral Anatomy, College of Stomatology, Dalian Medical University
-
- Huang Hai-tao
- Department of Dentistry, the First Affiliated Hospital of Dalian Medical University
-
- Xiao Jing
- Department of Oral Pathology, College of Stomatology, Dalian Medical University Department of Oral Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Search this article
Description
In order to analyze the potential teratogenic mechanism of RA in secondary palate development, we established RA-induced cleft palate (CP) model by using C57BL/6J mice and performed immunohistochemical staining by using Wnt5a, β-Catenin and Bcl-2 antibodies. Higher level expression of Wnt5a was detected in mesenchymal cells of secondary palate at E13 and the expression decreased from E14 in wild type. In RA-induced CP Wnt5a decreased severely at E15 and disappeared earlier. No relative of β-catenin and Wnt5a was detected in both wide type and RA-induced CP mouse. We also found the expression of Bcl-2 located in MEE cells of RA-induced CP group was restrained in horizontal stage of palate development.
Journal
-
- Journal of Hard Tissue Biology
-
Journal of Hard Tissue Biology 14 (2), 241-242, 2005
THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282679435545088
-
- NII Article ID
- 110005853543
-
- NII Book ID
- AA11074332
-
- ISSN
- 1880828X
- 13417649
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- Crossref
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed