A case achieving favorable pain relief and drug cost reduction with methadone

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  • メサドン使用により良好な鎮痛と薬剤費の軽減を得た1例
  • 症例 メサドン使用により良好な鎮痛と薬剤費の軽減を得た1例
  • ショウレイ メサドン シヨウ ニ ヨリ リョウコウ ナ チンツウ ト ヤクザイヒ ノ ケイゲン オ エタ 1レイ

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A 55-year-old woman, who was diagnosed with breast cancer, complained of severe pain due to skin metastasis, even though she took morphine 720 mg/day, fentanyl patch 200 mg/h, and some adjuvants. To improve pain relief, opioid switch with methadone was performed. Because she took high-dose opioids, an increase of methadone and a decrease of morphine and fentanyl were done gradually. Six months later after start of methadone, satisfied pain relief was obtained with methadone 120 mg/day and fentanyl 100 µg/h with no severe adverse events. Furthermore, the cost of opioids decreased from approximately 620,000 to 240,000 yen per month. With patients who need high-dose opioids, methadone may be useful because it offers both good pain relief and opioid cost reduction.

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