Enhanced Oral Bioavailability of Astaxanthin with Droplet Size Reduction

DOI 被引用文献13件 参考文献9件
  • AFFANDI M.M.R. MEOR MOHD
    Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA Malaysia
  • JULIANTO T.
    Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA Malaysia
  • MAJEED A.B.A.
    Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA Malaysia Research Management Institute, Universiti Teknologi MARA Malaysia

書誌事項

公開日
2012
DOI
  • 10.3136/fstr.18.549
公開者
公益社団法人 日本食品科学工学会

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説明

Astaxanthin is a natural xanthophyll abundantly found in Haematococcus pluvaris with strong antioxidant property and it is found to be useful in many biological functions. Recent scientific findings indicate that astaxanthin shows low oral bioavailability due to its lipophilicity. However, the influence of emulsion droplet size on astaxanthin bioavailability is yet to be studied. This study was performed to investigate the effects of emulsion droplet size reduction on the bioavailability of astaxanthin emulsion through oral administration. In vivo study was carried out to evaluate the rate and extent of absorption of macro and nanosized emulsion an oil solution formulation. The nanosized emulsion shows increased Cmax and AUC0-∞ and decreased Tmax values with a reduction of the emulsion globule size. The AUC0-∞ of nanosized compared to macrosized emulsion and oil solution was increased by 110% − 140% and 140% − 200% respectively.

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詳細情報 詳細情報について

  • CRID
    1390282679436280960
  • NII論文ID
    130002538056
  • DOI
    10.3136/fstr.18.549
  • COI
    1:CAS:528:DC%2BC38XhsFKgtrjF
  • ISSN
    18813984
    13446606
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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