書誌事項
- タイトル別名
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- Research for Identification of Tumor Suppressor Genes in Oral Cancer: Part 1
- コウクウ ヘンペイ ジョウヒガン ニ オケル ガン ヨクセイ イデンシ コウホ ノ ケンキュウ ソノ 1 4バン センショクタイ チョウワンブ ノ LOH カイセキ
- —4番染色体長腕部のLOH解析—
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説明
Tumor suppressor gene (TSG) has a very important role in cancer formation and squamous cell carcinoma (SCC) is the most common malignant tumor in oral region. So the aim of our study is a finding a new TSG in oral SCC.<br>Loss of Heterozygosity (LOH) is an effective means to discover TSG. In past studies, LOH has been frequently detected at chromosome 4q22-35 region in human oral SCC. This suggests the existence of tumor suppressor genes.<br>We analysed LOH at 4q22-35 region in 40 oral SCC casrs by using 17 microsatellite markers and found allelic deletions in 85% (34/40) of the significant cases. We detected two high LOH regions, one is around D4S2623 and the other is around D4S1644. D4S2623 showed the higher LOH frequency being 44%.<br>When we redefined the map of 4q22-35 region according to the contiguous sequences, we observed gene Caspase-6 in the proximity of D4S2623, which has a relevant function during apoptosis and therefore can also work like TSG.
収録刊行物
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- Journal of Hard Tissue Biology
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Journal of Hard Tissue Biology 12 (3), 75-81, 2003
硬組織再生生物学会
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詳細情報 詳細情報について
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- CRID
- 1390282679436398336
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- NII論文ID
- 110001142097
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- NII書誌ID
- AA11074332
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- ISSN
- 1880828X
- 13417649
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- NDL書誌ID
- 6960988
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 抄録ライセンスフラグ
- 使用不可
