De Novo Bone Formation Using Bovine Collagen and Platelet-rich Plasma in Animals

DOI Web Site 被引用文献3件 参考文献87件
  • MURATA Masaru
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido
  • ARISUE Makoto
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido

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Recently, pepsin-digested collagen (so-called atelocollagen) has been used for tissue engineering as one of the most useful scaffolds for bone formation. Its excellent biocompatibility, due to its biological characteristics such, as absorbable properties and low antigenicity, has elevated collagen to become a primary resource in medical applications. Platelet-rich plasma (PRP) is an autologous vehicle that delivers a highly concentrated dose of platelets containing osteopromotive factors, such as platelet-derived growth factor (PDGF), and transforming growth factor beta-1 and beta-2 (TGF-β1 and TGF-β2). These growth factors are thought to help to induce local mesenchymal and epithelial cells to migrate, divide, and increase collagen synthesis. In this paper, the characteristics of bovine collagen, PRP and animal studies using them for bone formation are reviewed.

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