Chemical Stimulation of a Cellular Tissue through a Microhole Array and Multichannel Potential Measurement Using a Microelectrode Array

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  • Omori Ryunosuke
    Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology
  • Morisako Isamu
    Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology
  • Kageyama Itsuki
    Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology
  • Natsume Kiyohisa
    Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology
  • Yasuda Takashi
    Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology

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  • 微小孔アレイを通じた細胞組織の薬剤刺激と微小電極アレイによる多点電位計測
  • ビショウコウ アレイ オ ツウジタ サイボウ ソシキ ノ ヤクザイ シゲキ ト ビショウ デンキョク アレイ ニ ヨル タテン デンイ ケイソク

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Abstract

<p>By forming multiple microholes and 64 microelectrodes at the center of a transparent SiN (silicon nitride) diaphragm, we developed a microdevice for chemical stimulation and multichannel measurement of extracellular potentials of cells and tissues. A rat hippocampal slice which was placed on the device was electrically stimulated using one of the 64 microelectrodes, and evoked potentials were measured at multiple areas of the slice. We chemically stimulated the slice by tetrodotoxin molecules released from the microholes, and succeeded in detecting disappearance of the potentials which was caused by inhibition of neural firing.</p>

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