Review of Glucose-Driven Decompression Device for a Chemical Controlled Artificial Pancreas

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  • Mitsubayashi Kohji
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

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  • グルコースにて作動する減圧機構と化学駆動・制御による人工すい臓モデルに関するレビュー
  • グルコース ニテ サドウ スル ゲンアツ キコウ ト カガク クドウ ・ セイギョ ニ ヨル ジンコウ スイゾウ モデル ニ カンスル レビュー

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Glucose-driven decompression device which utilizes conversion of chemical energy (glucose) to mechanical energy (actual pressure) has been developed and applied for a novel chemical controlled artificial pancreas system. The artificial system does not need to require any other power source such as electrical or mechanical energy. Integrated intermittent drug release actions and pressure changes were observed in record with CCD camera. The system was then evaluated in closed loop system setting for feedback control of the glucose concentration. The data revealed that drug release interval was extended causing stabilized constant glucose concentration on feedback effect. Accordingly, glucose concentration can be controlled autonomously similar with natural pattern of interdependent relationship between pancreas insulin secretion and glucose level. Potential applications of the organic engine include intelligent actuators, DDS (drug delivery system) and artificial muscles using biological energies (sugar, acid, lipid, etc.) with a neglibly-small heat loss.

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