Histometrical Study of Age Changes of the Arteries in Autopsied Submandibular Glands, and Relation with Age Changes of the Glands

DOI 被引用文献3件 参考文献19件
  • Ishikawa Ayataka
    Molecular Pathology, Graduate School of Tokyo Medical and Dental University Department of Pathology, Tokyo Metropolitan Hiroo General Hospital
  • Tanaka Michio
    Department of Pathology, Tokyo Metropolitan Hiroo General Hospital
  • Ogawa Takafumi
    Department of Pathology, School of Medicine, Kyorin University
  • Takagi Minoru
    Molecular Pathology, Graduate School of Tokyo Medical and Dental University

書誌事項

公開日
2003
DOI
  • 10.3353/omp.8.105
公開者
特定非営利活動法人 日本臨床口腔病理学会

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説明

We studied histometrically the degeneration with aging of the submandibular glands removed from 103 autopsied cadavers (0 ∼ 102 years old). To evaluate arteriosclerosis of the mediumand small-sized arteries and the arterioles in the glands, we determined the stenotic index (SI). We assessed the correlations between SI and degeneration in the glands, age, general physical conditions and underlying diseases. SI of the medium- and small-sized arteries and the arterioles correlated with age (p < 0.001). Whereas, the medium- and small-sized arteries had intimal fibro-elastosis, the arterioles had hyaline arteriosclerosis in young cases and, in addition, intimal fibro-elastosis in elderly cases. As for degeneration, SI correlated with the grade of fatty infiltration and fibrosis but not with lymphoplasmacytic cell infiltration. The findings suggest that arteriosclerosis of the arteries in the glands is one of the causes of atrophy of the glands. SI correlated strongly with the atherosclerotic grade of the aorta and moderately with the atherosclerotic grade of the coronary artery. SI correlated weakly with heart weight ? body weight ratio but not with BMI.

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