The Specific Inhibition of Brain-type Creatine Kinase by Z-Leu-Leu-Leu-H and its Derivatives
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- Iwayama Ken-ichi
- Graduate School of Science and Engineering, Aoyama Gakuin University
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- Ito Hisashi
- Graduate School of Science and Engineering, Aoyama Gakuin University
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- Yonemoto Kyozo
- Graduate School of Health Sciences, Tokyo Metropolitan University of Health Sciences
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- Kasai Hisataka
- Graduate School of Health Sciences, Tokyo Metropolitan University of Health Sciences
Bibliographic Information
- Other Title
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- 外因性神経突起伸長因子Z-Leu-Leu-Leu-Hおよびその誘導体による脳型クレアチンキナーゼの特異的阻害
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Abstract
Z-Leu-Leu-Leu-H (Z-LLL-H) is an exogenous neurite outgrowth factor. We have identified brain-type creatine kinase (BB-CK) as a target protein of Z-LLL-H. The purpose of this study was to examine the effects of Z-LLL-H and its derivatives on creatine kinase isozymes. BB-CK activity was strongly inhibited by addition of Z-LLL-H and was similarly inhibited by addition of the derivatives (Z-LLL-OMe, Z-LLL-OEt) esterified on the C-terminal. On the other hand, skeletal muscle-type creatine kinase (MM-CK) and cardiac muscle-type (MB-CK) were activated by Z-LLL-H. These results suggest that the inhibition of BB-CK activity may be correlated with the promotion of neurite outgrowth.
Journal
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- The Journal of Tokyo Academy of Health Sciences
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The Journal of Tokyo Academy of Health Sciences 7 (1), 31-34, 2004
Japan Academy of Health Sciences
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Details 詳細情報について
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- CRID
- 1390282679446468736
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- NII Article ID
- 110002345814
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- ISSN
- 2433149X
- 13443844
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed