Invited paper: Challenges of 3-D characterization of polymer-based drug delivery devices with cluster secondary ion mass spectrometry
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- Mahoney Christine M.
- National Institute of Standards and Technology
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- Fahey Albert J.
- National Institute of Standards and Technology
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- Belu Anna M.
- Medtronic Inc.
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- Gardella Jr. Joseph A
- Department of Chemistry, State University of New York at Buffalo
書誌事項
- タイトル別名
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- Challenges of 3-D characterization of polymer-based drug delivery devices with cluster Secondary Ion Mass Spectrometry
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抄録
Three-dimensional (3-D) molecular imaging in polymeric biomaterials, particularly in the near surface region (1 nm to 500 nm), is extremely important for drug delivery applications, as these regions play a vital role in both the biocompatability and drug release characteristics in drug delivery systems. Although pharmaceutical companies typically use dissolution studies to monitor the rate of drug release, these studies need to be correlated with actual structural information, compositions and defects within the device. This work discusses the most recent advances and challenges in utilizing Cluster Secondary Ion Mass Spectrometry (cluster SIMS) for 3-D characterization and quantification in polymer-based drug delivery systems. The results are promising, showing the ability to quantify and image the 3-dimensional distribution of drugs in polymer layers. However, many problems still remain in terms of analysis of real-world samples, including complex sample geometries, ionization effects, and beam-induced sample damage. These problems, and how to address them, are discussed briefly here.
収録刊行物
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- Journal of Surface Analysis
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Journal of Surface Analysis 17 (3), 299-304, 2011
一般社団法人 表面分析研究会
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詳細情報 詳細情報について
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- CRID
- 1390282679448032128
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- NII論文ID
- 130005138961
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- NII書誌ID
- AA11448771
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- ISSN
- 13478400
- 13411756
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- NDL書誌ID
- 11077673
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可