Establishment of Patient-derived tumor xenograft (PDX) model and application for precision cancer medicine.

DOI
  • Okada Seiji
    Division of Hematopoiesis, Center for AIDS Research, Kumamoto University

Bibliographic Information

Other Title
  • 患者腫瘍移植マウスモデル（Patient-Derived Tumor Xenograft：PDX）とその活用
  • −個別化がん治療（Precision Cancer Medicine）に向けて−

Search this article

Description

<p>Patient-derived xenograft (PDX) models can be created with transplantation of cancerous cells or tissues from patient’s primary tumors into immunodeficient mice. PDX technology leads to the breakthrough with the introduction of novel highly immunodeficient mice such as NOG (NOD/Scid/IL2Rγnull), NSG (NOD/Scid/IL2Rγnull), and NOJ (NOD/Scid/Jak3null) mice. As PDX has been shown to conserve human original tumor characteristics, it is now getting standard methods to evaluate the drug sensitivity, and PDX library is now established in many organization with integrated genomic signature. These PDX data base are getting powerful tool for advancing Precision Cancer Medicine.</p>

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top