Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

  • Kairupan Tara Sefanya
    Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences Faculty of Medicine, Sam Ratulangi University
  • Ibusuki Rie
    Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
  • Kheradmand Motahare
    Mazandaran University of Medical Sciences
  • Sagara Yasuko
    Japanese Red Cross Kyushu Block Blood Center
  • Mantjoro Eva Mariane
    Faculty of Public Health, Sam Ratulangi University
  • Nindita Yora
    Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences Faculty of Medicine, Diponegoro University
  • Niimura Hideshi
    Yonemori Hospital
  • Kuwabara Kazuyo
    Department of Preventive Medicine and Public Health, Keio University School of Medicine
  • Ogawa Shin
    National Health Insurance Yamato Clinic
  • Tsumematsu-Nakahata Noriko
    Department of Community Medicine Management, Faculty of Medicine, Shimane University
  • Nerome Yasuhito
    Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences
  • Owaki Tetsuhiro
    Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences
  • Matsushita Toshifumi
    Japan Health Club
  • Maenohara Shigeho
    JA Kagoshima Kouseiren Medical Health Care Center
  • Yamaguchi Kazunari
    National Institute of Infectious Diseases
  • Takezaki Toshiro
    Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences

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<p>Background: An increased risk of total death owing to human T-lymphotropic virus type-I (HTLV-I) infection has been reported. However, its etiology and protective factors are unclear. Various studies reported fluctuations in immune-inflammatory status among HTLV-I carriers. We conducted a matched cohort study among the general population in an HTLV-I-endemic region of Japan to investigate the interaction between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases.</p><p>Method: We selected 2180 sub-cohort subjects aged 35–69 years from the cohort population, after matching for age, sex, and region with HTLV-I seropositives. They were followed up for a maximum of 10 years. Inflammatory gene polymorphisms were selected from TNF-α, IL-10, and NF-κB1. A Cox proportional hazard model was used to estimate the hazard ratio (HR) and the interaction between gene polymorphisms and HTLV-I for risk of total death and incidence of cancer and atherosclerosis-related diseases.</p><p>Results: HTLV-I seropositivity rate was 6.4% in the cohort population. The interaction between TNF-α 1031T/C and HTLV-I for atherosclerosis-related disease incidence was statistically significant (p = 0.020). No significant interaction was observed between IL-10 819T/C or NF-κB1 94ATTG ins/del and HTLV-I. An increased HR for total death was observed in the Amami island region, after adjustment of various factors with gene polymorphisms (HR 3.03; 95% confidence interval, 1.18–7.77).</p><p>Conclusion: The present study found the interaction between TNF-α 1031T/C and HTLV-I to be a risk factor for atherosclerosis-related disease. Further follow-up is warranted to investigate protective factors against developing diseases among susceptible HTLV-I carriers.</p>

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