Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population
-
- Kairupan Tara Sefanya
- Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences Faculty of Medicine, Sam Ratulangi University
-
- Ibusuki Rie
- Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
-
- Kheradmand Motahare
- Mazandaran University of Medical Sciences
-
- Sagara Yasuko
- Japanese Red Cross Kyushu Block Blood Center
-
- Mantjoro Eva Mariane
- Faculty of Public Health, Sam Ratulangi University
-
- Nindita Yora
- Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences Faculty of Medicine, Diponegoro University
-
- Niimura Hideshi
- Yonemori Hospital
-
- Kuwabara Kazuyo
- Department of Preventive Medicine and Public Health, Keio University School of Medicine
-
- Ogawa Shin
- National Health Insurance Yamato Clinic
-
- Tsumematsu-Nakahata Noriko
- Department of Community Medicine Management, Faculty of Medicine, Shimane University
-
- Nerome Yasuhito
- Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences
-
- Owaki Tetsuhiro
- Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences
-
- Matsushita Toshifumi
- Japan Health Club
-
- Maenohara Shigeho
- JA Kagoshima Kouseiren Medical Health Care Center
-
- Yamaguchi Kazunari
- National Institute of Infectious Diseases
-
- Takezaki Toshiro
- Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
この論文をさがす
説明
<p>Background: An increased risk of total death owing to human T-lymphotropic virus type-I (HTLV-I) infection has been reported. However, its etiology and protective factors are unclear. Various studies reported fluctuations in immune-inflammatory status among HTLV-I carriers. We conducted a matched cohort study among the general population in an HTLV-I-endemic region of Japan to investigate the interaction between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases.</p><p>Method: We selected 2180 sub-cohort subjects aged 35–69 years from the cohort population, after matching for age, sex, and region with HTLV-I seropositives. They were followed up for a maximum of 10 years. Inflammatory gene polymorphisms were selected from TNF-α, IL-10, and NF-κB1. A Cox proportional hazard model was used to estimate the hazard ratio (HR) and the interaction between gene polymorphisms and HTLV-I for risk of total death and incidence of cancer and atherosclerosis-related diseases.</p><p>Results: HTLV-I seropositivity rate was 6.4% in the cohort population. The interaction between TNF-α 1031T/C and HTLV-I for atherosclerosis-related disease incidence was statistically significant (p = 0.020). No significant interaction was observed between IL-10 819T/C or NF-κB1 94ATTG ins/del and HTLV-I. An increased HR for total death was observed in the Amami island region, after adjustment of various factors with gene polymorphisms (HR 3.03; 95% confidence interval, 1.18–7.77).</p><p>Conclusion: The present study found the interaction between TNF-α 1031T/C and HTLV-I to be a risk factor for atherosclerosis-related disease. Further follow-up is warranted to investigate protective factors against developing diseases among susceptible HTLV-I carriers.</p>
収録刊行物
-
- Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ
-
Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ 27 (9), 420-427, 2017
日本疫学会