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THE LINKAGE BETWEEN INNATE IMMUNITY AND ALLERGIC INFLAMMATION FROM THE POINT OF VIEW OF DENDRITIC CELL FUNCTION
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- Yasutomi Motoko
- Department of Pediatrics, Fukui Insurance Hospital
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- Ohshima Yusei
- Department of Pediatrics, Faculty of Medical Sciences, University of Fukui
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- Mayumi Mitsufumi
- Department of Pediatrics, Faculty of Medical Sciences, University of Fukui
Bibliographic Information
- Other Title
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- 樹状細胞機能からみた自然免疫とアレルギー性炎症との接点
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Description
Anti-inflammatory effects of erythromycin have drawn notice to its clinical application for chronic respiratory inflammatory diseases. Since dendritic cells have been shown to play pivotal roles in antigen sensitization and exacerbation of allergic inflammation, we examined the effects of erythromycin on the function of dendritic cells activated with pathogen-derived stimuli and helper T cell activation. As a results, erythromycin selectively inhibited expressions of costimulatory molecules and cytokine production by dendritic cells stimulated with poly (I:C) and LPS, but not with peptidoglycan. Erythromycin suppressed IFN regulatory factor-3 activation and IFN-β production induced by poly(I:C) and LPS, and suppressed poly (I:C)-mediated differentiation of naïve T cells into Th1 effector cells. Moreover, erythromycin suppressed IL-17 production by memory T cells that were activated by PGN-stimulated dendritic cells. These results collectively suggest that erythromycin presents anti-inflammatory effects depending on the nature of pathogen-derived stimuli, and thereby modulates allergic inflammation.
Journal
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- Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
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Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 22 (2), 253-258, 2008
THE JAPANESE SOCIETY OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY
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Details 詳細情報について
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- CRID
- 1390282679451362688
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- NII Article ID
- 130004504163
- 10026940285
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- NII Book ID
- AN10064415
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- ISSN
- 18822738
- 09142649
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed