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The Effect of Low-Energy Laser Irradiation with Helium Neon Laser on the Growth of Malignant Tumor Cells

  • NAKANO Kenjiro
    Department of Operative Dentistry, School of Dentistry, Aichi Gakuin University
  • AOYAMA Goudai
    Department of Operative Dentistry, School of Dentistry, Aichi Gakuin University
  • NARUHASHI Masayoshi
    Department of Operative Dentistry, School of Dentistry, Aichi Gakuin University
  • YAMADA Mitsuyoshi
    Department of Operative Dentistry, School of Dentistry, Aichi Gakuin University
  • SATO Kaori
    Department of Operative Dentistry, School of Dentistry, Aichi Gakuin University
  • KUBO Katsutoshi
    Department of Oral Pathology School of Dentistry, Aichi Gakuin University
  • YOSHIDA Waka
    Department of Oral Pathology School of Dentistry, Aichi Gakuin University
  • FUJITANI Morioki
    Department of Operative Dentistry, School of Dentistry, Aichi Gakuin University
  • MAEDA Hatsuhiko
    Department of Oral Pathology School of Dentistry, Aichi Gakuin University
  • SENDA Akira
    Department of Operative Dentistry, School of Dentistry, Aichi Gakuin University

Bibliographic Information

Other Title
  • ヘリウムネオンレーザーによる低エネルギーレーザー照射が腫瘍細胞に及ぼす影響

Abstract

Clinical studies have revealed that low-energy laser irradiation facilitates alleviation of pain or wound healing. However, basic studies have demonstrated that irradiation using low-energy laser such as He-Ne laser modulates various biological processes. Some reports found that He-Ne laser irradiation activated the cell cycle and stimulated cell proliferation activity, while others suggested that it indicated inhibitory behavior. Further elucidation of the photo-chemical effects of low-energy laser irradiation on cultured cells is required. The present report reviews our studies on the effects of low-energy laser irradiation with He-Ne laser.<br>We have also been examining the effects of He-Ne laser irradiation on the proliferation activity of rat bone-marrow-derived osteoblastic cells cultured on TiO2 discs. The results suggest that He-Ne laser irradiation stimulates both the proliferation and differentiation capacity of the cells. Therefore, He-Ne laser irradiation around an implant hole prior to pegging an implant body might promote healing of bone tissue and contribute to an initial fixation of a dental implant, leading to an increase in the graft survival rate.<br>We also examined the effects of He-Ne laser irradiation on the growth of mouse colonic-carcinoma-derived tumor cells. The results showed that brief irradiation stimulated proliferation of the cells, whereas prolonged irradiation caused cytostatic activity of the cells.<br>These studies revealed that the effects of low-energy laser irradiation on various cells differ according to the kind of laser, irradiation time, and amount of energy as well as the kind of cells. Further studies on the photo-chemical effects of low-energy laser irradiation are necessary.

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Details

  • CRID
    1390282679451431040
  • NII Article ID
    130004565006
  • DOI
    10.5984/jjpnsoclaserdent.21.173
  • ISSN
    2185-6702
    0917-7450
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
    • Crossref
    • KAKEN

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