Experimental Study of Interstitial Photodynamic Therapy to Improve Therapeutic Value

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  • TANAKA Hideo
    Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine
  • YAMADA Ichiro
    Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine
  • MASUMOTO Kazuma
    Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine
  • MURAI Mutsuhiko
    Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine
  • YAMAGUCHI Kazue
    Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine
  • SHIKIMORI Michio
    Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine
  • HASHIMOTO Kenji
    Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine

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  • 組織内照射法による光線力学療法の適応拡大に関する基礎研究

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Abstract

The purpose of this study was to evaluate interstitial photodynamic therapy using the Microselectron ® Flexible implant tube (Nucletron B. V.) for advanced cancer. VX2 carcinoma was transplanted subcutaneously into the femur of Japanese white rabbits. When the cancer grew to the size of 60 mm, a dose of 10 mg/kg of porfimer sodium (Photofrin ®, Wyeth Lederle Japan Ltd.) was administered intravenously. Microselectron ® tubes were implanted into the tumor at intervals of 20mm in which the optic fiber was inserted. Then irradiation was performed under conditions of 4mJoul/pulse and a pulse repetition frequency of 80Hz. The total light dose along a tube was 100Joul/cm. At 5 days after irradiation, the tumors had flatted, due to necrotic change. We suggest that interstitial photodynamic therapy using the Microselectron ® tube is applicable for treatment of solid oral cancer.

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