Gastroduodenal Ulcers and ABO Blood Group: the Japan Nurses’ Health Study (JNHS)
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- Alkebsi Lobna
- Department of Laboratory Sciences, Graduate School of Health Sciences, Gunma University
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- Ideno Yuki
- Big Data Centre for Integrative Analysis, Gunma University Initiative for Advanced Research
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- Lee Jung-Su
- Department of Health Promotion Science, Graduate School of Medicine, The University of Tokyo
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- Suzuki Shosuke
- Professor Emeritus, Gunma University and NPO International Eco-Health Research Group
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- Nakajima-Shimada Junko
- Department of Molecular and Cellular Parasitology, Graduate School of Health Sciences, Gunma University
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- Ohnishi Hiroshi
- Department of Laboratory Sciences, Graduate School of Health Sciences, Gunma University
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- Sato Yasunori
- Department of Global Clinical Research, Graduate School of Medicine, Chiba University
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- Hayashi Kunihiko
- Department of Basic Medical Sciences, Graduate School of Health Sciences, Gunma University
書誌事項
- 公開日
- 2018
- 資源種別
- journal article
- DOI
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- 10.2188/jea.je20160204
- 公開者
- 日本疫学会
この論文をさがす
説明
<p>Background: Although several studies have shown that blood type O is associated with increased risk of peptic ulcer, few studies have investigated these associations in Japan. We sought to investigate the association between the ABO blood group and risk of gastroduodenal ulcers (GDU) using combined analysis of both retrospective and prospective data from a large cohort study of Japanese women, the Japan Nurses’ Health Study (JNHS; n = 15,019).</p><p>Methods: The impact of the ABO blood group on GDU risk was examined using Cox regression analysis to estimate hazard ratios (HRs) and 95% confidence intervals (CI), with adjustment for potential confounders.</p><p>Results: Compared with women with non-O blood types (A, B, and AB), women with blood type O had a significantly increased risk of GDU from birth (multivariable-adjusted HR 1.18; 95% CI, 1.04–1.34). Moreover, the highest cumulative incidence of GDU was observed in women born pre-1956 with blood type O. In a subgroup analysis stratified by birth year (pre-1956 or post-1955), the multivariable-adjusted HR of women with blood type O was 1.22 (95% CI, 1.00–1.49) and 1.15 (95% CI, 0.98–1.35) in the pre-1956 and post-1955 groups, respectively.</p><p>Conclusion: In this large, combined, ambispective cohort study of Japanese women, older women with blood type O had a higher risk of developing GDU than those with other blood types.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ 28 (1), 34-40, 2018
日本疫学会