Late Functioning Virilizing Adrenocortical Adenoma in An 8-Year-Old Girl

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  • Arisaka Osamu
    Department of Pediatrics, Juntendo University School of Medicine
  • Shimura Naoto
    Department of Pediatrics, Juntendo University School of Medicine
  • Wada Toshio
    The First Division, Department of Pathology, Juntendo University School of Medicine
  • Hosaka Atsuto
    Department of Pediatrics, Juntendo University School of Medicine
  • Nakayama Yuko
    Department of Pediatrics, Juntendo University School of Medicine
  • Fujiwara Sachi
    Department of Pediatrics, Juntendo University School of Medicine
  • Arisaka Madoka
    Department of Pediatrics, Juntendo University School of Medicine
  • Nishi Yoshikazu
    Department of Pediatrics, Hiroshima Red Cross Hospital
  • Yabuta Keijiro
    Department of Pediatrics, Juntendo University School of Medicine

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説明

We describe an unusual presentation of virilizing adrenal adenoma in a prepubertal girl. The patient's adrenal mass had been detected incidentally at one year of age, but no clinical signs were evident until the appearance of pubic hair at 7 years of age. Plasma testosterone concentration was elevated (166ng/dl), but further endocrinological examination revealed prominent elevation of δ5-pregnene steroids including 17-hydroxypregnenolone, dehydroepiandrosterone and dehydroepiandrosterone-sulfate. Finally, a diagnosis of adrenocortical adenoma was made after surgical resection. This adrenal tumor, clinically non-functional early, was considered to be “late functioning”.

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