<b>5. Application of Japanese Claims Database to Pharmacovigilance Activity in Pharmaceutical Industry; Analysis on Cancer Incidences and Usage of Anticancer Agents </b>

DOI 2 Citations 8 References
  • HAMADA Kenji
    Epidemiology Group, Pharmacovigilance Department, Drug Safety Division, Chugai Pharmaceutical Co., Ltd.
  • AOKI Kotonari
    Epidemiology Group, Pharmacovigilance Department, Drug Safety Division, Chugai Pharmaceutical Co., Ltd.

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Other Title
  • <b>5．データベース活用事例の紹介; 製薬企業の立場から　レセプト(JMDC提供) </b>
  • 5. Application of Japanese Claims Database to Pharmacovigilance Activity in Pharmaceutical Industry; Analysis on Cancer Incidences and Usage of Anticancer Agents
  • <b>がんの発生動向と抗がん剤投与後の疾患動向の解析を例に </b>

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Application of a Japanese insurance claims database to pharmacovigilance activities in pharmaceutical industry was discussed. Using a commercially available insurance claims database, incidences of several cancers, the number of patients who were administered anticancer agents, and possible adverse effects were studied. Cancer incidences obtained from the database were virtually equivalent to those from a traditional survey program. The number of cancer patients included in the database with one million beneficiaries, were a few thousands a year. Disorders in epithelial-derived tissue were observed more frequently in lung cancer patients after the initiation of EGF tyrosine kinase inhibitor therapy than after platinum-based therapy, suggesting possible candidates of adverse effects of the EGF tyrosine kinase. We concluded that an estimation of disease incidence and selecting candidates of adverse events with the claims database is theoretically possible. And the database is also applicable to pharmacovigilance fields. (Jpn J Pharmacoepidemiol 2012; 17(2): 145-153)

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