<b>Case-Control Study within a Cohort</b>

  • TAKEUCHI Hisao
    Clinical Management, Clinical Development Center, Asahi Kasei Pharma Corporation
  • KAGIMURA Tatsuo
    Department of Statistical Analysis, Translational Research Informatics Center, Foundation for Biomedical Research and Innovation

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  • <b>1. コホート内ケース・コントロール研究</b>
  • Case-Control Study within a Cohort

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In this article, we provide a brief summary of study design of case-control study within a cohort and an introduction of two case-control studies within a cohort conducted in Japan recently using antihypertensive drug database based on the post-marketing surveillance data of pharmaceutical companies. In the case-control study within a cohort, it is possible to avoid bias caused in a case-control study and conduct more efficiently than cohort study. Therefore the case-control study within a cohort widely has been used in pharmacoepidemiological studies with a database. (Jpn J Pharmacoepidemiol 2013; 18(2): 77-83)

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