二酸化チタンの発がん性評価

江馬 眞, 小林 憲弘, 納屋 聖人, 花井 荘輔, 中西 準子

doi:10.11403/jset.13.15

書誌事項

タイトル別名

Review of Carcinogenicity of Titanium Dioxide

説明

The present paper reviews the carcinogenicity study of titanium dioxide（TiO₂），widely used in the production of paints paper and plastics, as food additives and colorants, and increasingly, as nanpoparticles in pharmaceutical and cosmetics products, based on data published in openly available scientific literature. Increased incidence of tumors was reported in rats after exposure to respirable, fine or ultrafine TiO₂ by inhalation or intratracheal instillation. No increased incidence of tumors was noted in mice or hamster after exposure to TiO₂ by inhalation or intratracheal instillation, or in rats or mice given TiO2 by intraperitoneal or subcutaneous injection or by feeding. This review indicates that the incidence of tumors was increased in rats after inhalation or intratracheal instillation of TiO₂　at levels associated with particle overload and persistent inflammation.

収録刊行物

環境毒性学会誌

環境毒性学会誌 13 (1), 15-26, 2010

日本環境毒性学会

キーワード

詳細情報詳細情報について

CRID: 1390282679462254080

NII論文ID: 130004542790

DOI: 10.11403/jset.13.15

ISSN: 18825958; 13440667

本文言語コード: ja

データソース種別

JaLC
CiNii Articles

抄録ライセンスフラグ: 使用不可

書き出し

問題の指摘