野生哺乳動物への影響評価におけるバイオマーカーとしてのP450の有用性

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  • Cytochrome P450 : The useful biomarker to assess the influences of environmental pollutants on wild mammals
  • ヤセイホニュウドウブツ エ ノ エイキョウ ヒョウカ ニ オケル バイオマーカー ト シテ ノ P450 ノ ユウヨウセイ

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説明

Cytochrome P450 (CYP) multiple enzyme system plays a major role in oxidative metabolism of a broad variety of endogenous and exogenous compounds, including sterols, fatty acids, drugs and xenobiotics. Some CYP isozymes are known to be induced by xenobiotics, including environmental pollutants. In order to estimate the suitability of using CYP as indicator of environment, we have been investigated about the CYP-dependent activities in hepatic microsomes of feral rodent (Clethrionomys rufocanus) and marine mammal (Phoca largha). From the results of our investigations, it can be concluded that the CYP-dependent activities are useful biomarkers of environmental pollution.

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