Relationship between temperature and pharmacokinetic parameters of florfenicol in carp (<I>Cyprinus carpio</I>)

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  • Relationship between Temperature and Pharmacokinetic Parameters of Florfenicol in Carp (Cyprinus carpio)

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We evaluated the relation between oxygen consumption rate (MO2), which correlates with water temperature and pharmacokinetic parameters of florfenicol (FFC) in carp (Cyprinus carpio). We administered FFC (dose, 10 mg/kg) intravascularly or orally to fish at 8, 14, 18, and 23°C. Blood was intermittently sampled via cannulae for 170 h, and the concentration of FFC in the serum was measured. We also determined the (MO2) at each temperature. Data were analyzed using a 1-compartment pharmacokinetic model, and absorption (ka) and elimination (ke) rate constants were estimated. We found that both ka and ke varied exponentially with (MO2) (r = 0.92 and 0.93 respectively) and with temperature (r = 0.91 and 0.94 respectively). These findings clearly demonstrate that the rates of absorption and elimination of FFC in carp decrease as (MO2) and water temperature drop.

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