Clinical Management of Tuberculosis Infection in Nonhuman Primates

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  • サル類における結核症の臨床

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Thirty two cases of tuberculosis infections in cercopithecid monkeys had been encountered at the Primate Research Institute, Kyoto University, during the period of 1971 to 1984. Among them, in 1971, tuberculosis outbreak of 21 Rhesus macaques occurred within populations that were under quarantine period and usually housed in the cage rooms. These animals were diagnosed by pathological and bacteriological analyses. The outbreaks were caused by reservoir animals that had already been infected before introduction. In 1985, two cases of suspected tuberculosis infections in chimpanzee and orang utan were observed, responding to intradermal mammalian old tuberculin (MOT) in the quarantine yards. 2 apes did not showed any clinical symptoms, nor characteristic X ray findings, hematological and blood chemistry values, while lymphadenopathy were observed in the orang utan. Bacteriological trials for detecting pathogenic mycobacterin from Laryngo pharyngeal and tracheal mucus and gastro washing juices showed negative results. It is supposed that 2 apes had already been infected before introduction by 2 zookeepers, who were under medication on tuberculosis. Prophylactic oral medication by Isoniazid and Rifampicin were performed daily during one year, monitoring MOT reactions and bacteriological detections. These suspected tuberculosis infections could be controlled successfully.

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