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- McClure Marcella A.
- Department of Biological Sciences, UNLV.
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- Hudak Julianna
- Department of Biological Sciences, UNLV.
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- Kowalski John
- Department of Biological Sciences, UNLV.
Bibliographic Information
- Other Title
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- Independent Modeling of the Ordered-Series-of-Motifs and Motif-Intervening-Regions
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Description
We present a strategy for generating a multiple alignment from a hidden Markov model (HMM) for low identity, low similarity protein sequences. In this approach the ordered-series-of-motifs and the motif-intervening-regions are independently modeled. We also provide a measure of multiple alignment “goodness” called the stability function to compared one alignment to another. This strategy provides a more robust HMM representing highly divergent sequence data.
Journal
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- Genome Informatics
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Genome Informatics 9 183-192, 1998
Japanese Society for Bioinformatics
