Health Effects of Endocrine Disruptors.

NAGAO Tetsuji

doi:10.1248/jhs1956.44.151

Several reports on the decreasing quantity of sperm production in human over the last four decades and on the increased incidence of certain cancers and endometriosis have increased concern about environmental chemicals, i.e., drugs, agricultural and industrial chemicals, and dioxins that can disrupt the endocrine system, although no link has been established between an endocrine-based disease and exposure to an environmental chemicals. Therefore, there is accumulating evidence that wild animals have suffered adverse reproductive consequences from exposure to environmental chemicals and a wide variety of environmental chemicals has been identified to have ability to interact with the endocrine system. Moreover, it is well recognized that the normal functions of all organ systems are regulated by endocrine factors, and small disturbances in the endocrine function, especially during certain stages of the life cycle such as development, pregnancy, and lactation, can lead to profound and lasting effects. Here, I compile representative classes of possible endocrine disruptors, and review the toxicities in animal models and possible mechanisms proposed to explain their effects as endocrine disruptors.

Health Effects of Endocrine Disruptors.

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