ブラストサイジンSの化学的定量法

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タイトル別名
  • Chemical Determination of Blasticidin S

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説明

Three different methods have been developed for chemical detemination of Blasticidin S, an anti-phytopathogenic fungal substance. Blasticidin S hydrochloride could be isolated from contaminants by thin-layer chromatography and submitted to determination procedures. Blasticidin S exhibited an intensive absorption at 275 mμ in acidic medium and the calibration curve showed a sufficient linearity for determination. Colorimetry of Blasticidin S was also performed by the color produced with sodium chromotropate and formaldehyde, formed by the oxidative decomposition of the N-methyl group in Blasticidin S with potassium permanganate. On the other hand, Blasticidin S was degraded by heating with hydroxylamine and diazo-coupling reaction of the resulting product with diazosulfanilate was capable of colorimetric determination of Blasticidin S.

収録刊行物

  • 衛生化学

    衛生化学 10 (3), 154-156, 1964

    公益社団法人 日本薬学会

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