Oral Toxicity of Sodium Dodecyl Sulfate

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  • ドデシル硫酸ナトリウムの長期毒性試験

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Weanling male rats were bred with a drinking water containing sodium dodecyl sulfate (SDS) at concentrations of 0.25, 0.05, or 0% for 5 months. Increase of organ weights was observed in the lung and kidney, though body weight was not affected at a higher concentration (0.25%). Histopathology of major organs indicated the characteristic symptom to be bronchopneumonia by the continued ingestion of a small amount of SDS. Activities of serum enzymes, such as GOT, GPT, alkaline phosphatase, and cholinesterase, were not affected at the dosages used. In rats taking 0.25% of SDS, triglyceride level increased in the liver but decreased in serum, while hepatic and serum levels of cholesterol, phospholipid, and free fatty acid were unchanged.

Journal

  • Eisei kagaku

    Eisei kagaku 24 (2), 107-110, 1978

    The Pharmaceutical Society of Japan

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