書誌事項
- タイトル別名
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- Studies on the Mutagenicity of o-Dinitrobenzene-nucleic Base Adducts in Salmonella typhimurium Strains and the Structural Elucidation of the Purine Adducts.
抄録
o-Dinitrobenzene (DNBz) and each nucleic base were made to react with NaOH in dimethylsulfoxide at room temperature for 3-60 h. All of the synthesized compounds were the 2-nitrophenyl adducts of nucleic bases. The mutagenicity test of the synthesized compounds and of o-DNBz were then carried out against Salmonella typhimurium TA98, TA98NR and TA100 without a mammalian metabolic activation system. o-DNBz has no mutagenic potency against all the strains at a dose up to 100 μg. In the compounds with the adducts of nucleic bases, the mutagenic potencies of the adducts of adenine and guanine in TA98 were 50 revertants/100 μg and 255 revertants/10 μg, respectively and the most potent mutagen in TA100 was an adduct of guanine (382 revertants/100μg). Finally, the structures of the adducts of adenine and guanine could be elucidated as N1-(2-nitrophenyl)-adenine and N1-(2-nitrophenyl)-guanine, respectively, by the acid and alkaline degradation and by the isopentyl nitrite treatment of these adducts.
収録刊行物
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- 衛生化学
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衛生化学 38 (4), 342-348, 1992
公益社団法人 日本薬学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679473398272
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- NII論文ID
- 130003748510
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- ISSN
- 0013273X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可