Abietic acid from Resina Pini of Pinus species as a testosterone 5α-reductase inhibitor
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- Roh Seong-Soo
- Department of Preparatory Oriental Medicine, College of Oriental Medicine, Daegu Haany University
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- Park Moon-Ki
- Department of Herbal Pharmaceutical Engineering, College of Herbal Bio-industry, Daegu Haany University
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- Kim Yong-ung
- Department of Herbal Pharmaceutical Engineering, College of Herbal Bio-industry, Daegu Haany University
書誌事項
- タイトル別名
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- Abietic Acid from Resina Pini of Pinus Species as a Testosterone 5.ALPHA.-Reductase Inhibitor
- Abietic acid from Resina Pini of Pinus species as a testosterone 5 a reductase inhibitor
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The 50% ethanol extracts from Resina Pini of Pinus sp. (Pinaceae) showed more potent inhibitory activity against testosterone 5α-reductase prepared from rat prostate than those from several medicinal plants used for the treatment of androgen-dependent diseases such as benign prostatic hyperplasia. The fraction responsible for this activity was purified, and the active constituent was isolated and identified as abietic acid, a diterpene resin acid, which exhibited potent testosterone 5α-reductase inhibitory activity. Methyl abietate was substantially inactive against testosterone 5α-reductase, whereas other diterpene resin acids, pimaric acid and neoabietic acid, were as active as abietic acid against testosterone 5α-reductase, indicating that the negatively charged anionic carboxyl group on the molecule is an important structural moiety for the inhibitory activity. These findings suggest that a nonsteroidal anionic diterpene compound of natural origin may have the potential to act as a transition state analogue inhibitor of testosterone 5α-reductase in the treatment of androgen-dependent diseases.
収録刊行物
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- JOURNAL OF HEALTH SCIENCE
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JOURNAL OF HEALTH SCIENCE 56 (4), 451-455, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679473834496
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- NII論文ID
- 130000303544
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- NII書誌ID
- AA11316464
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- ISSN
- 13475207
- 13449702
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- NDL書誌ID
- 10764180
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 使用不可