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Metallothionein-Null Mice Are Sensitive to Endotoxine/D-Galactosamine-Induced Hepatotoxicity.
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- Kimura Tomoki
- Department of Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University
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- Koujitani Takatoshi
- Department of Toxicology and Teratology, Developmental Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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- Itoh Norio
- Department of Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University
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- Takehara Miyako
- Department of Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University
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- Oguro Ikuyo
- Department of Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University
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- Ishizaki Jun-ichi
- Department of Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University
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- Nakanishi Tsuyoshi
- Department of Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University
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- Tanaka Keiichi
- Department of Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University
Bibliographic Information
- Other Title
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- Metallothionein-Null Mice Are Sensitive to Endotoxine/D-Galactosamine-Induced Hepatoxicity
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Description
Metallothionein (MT), which is a low-molecular weight, cysteine-rich, metal-binding protein, is induced during acute-phase reactions. However, the specific function of MT in the acute-phase response remains to be elucidated. We previously reported that MT-I, II deficient (MT-null) mice are highly sensitive to the lethal effects of lipopolysaccharide (LPS)/D-galactosamine (GalN). We designed the present study to clarify the major cause of the differences in the sensitivity to the lethal effects of LPS/GalN between wild type and MT-null mice. We found that histological grade of hepatocellular necrosis, induced by LPS/GalN, was greater in MT-null mice than in wild type mice. Therefore, the present findings suggest that MT induction has the potential as an attenuator of LPS/GalN-induced liver necrosis
Journal
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- Journal of Health Science
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Journal of Health Science 47 (3), 310-313, 2001
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679473891712
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- NII Article ID
- 110003641408
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- NII Book ID
- AA11316464
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- COI
- 1:CAS:528:DC%2BD3MXktVygsLo%3D
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- ISSN
- 13475207
- 13449702
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- NDL BIB ID
- 5799016
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed