Comparison of Antibacterial Activity of Fluoroquinolones with Their Sucralfate-complexes against Clinically-isolated Bacteria
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- Kawazoe Hitoshi
- Department of Clinical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School Department of Pharmacy, Kagawa University Hospital Present address: Division of Pharmacy, Ehime University
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- Takaoka Kyoko
- Department of Clinical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
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- Shibata Hirofumi
- Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
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- Arakaki Naokatu
- Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
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- Higuti Tomihiko
- Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
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- Negayama Kiyoshi
- Department of Clinical Laboratory, Kagawa University Hospital
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- Houchi Hitoshi
- Department of Pharmacy, Kagawa University Hospital
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- Tsuchiya Koichiro
- Department of Clinical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
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- Takiguchi Yoshiharu
- Department of Clinical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School
この論文をさがす
説明
Oral fluoroquinolones are widely known to form chelate complexes with metal-containing drugs, resulting in inhibition of their intestinal absorption. However, for intestinal sterilization, the concomitant regimen may be a selective and effective strategy due to decreased absorption of fluoroquinolones result in the retainment of antibiotics at the intestine if the mixture still perpetuated antibacterial activity. Therefore, to clarify whether the mixture of fluoroquinolones and sucralfate affects their antibacterial activity or not, we conducted in vitro study. According from the checkerboard study using a microdilution method with Mueller-Hinton broth, the antibacterial activity of these fluoroquinolones-sucralfate mixtures equaled to the parent fluoroquinolones even in the presence of sucralfate at the molar ratio of [sucralfate: fluoroquinolone] was less than 166, and the minimal inhibitory concentrations for clinical isolated Escherichia coli and Pseudomonas aeruginosa strains were independent of the existence of sucralfate. These data imply that the chelated forms of each fluoroquinolone retain antibacterial activity even in the presence of the recommended therapeutic doses of sucralfate in clinical practice.
収録刊行物
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- JOURNAL OF HEALTH SCIENCE
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JOURNAL OF HEALTH SCIENCE 55 (5), 790-795, 2009
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679474052224
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- NII論文ID
- 130000127968
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- NII書誌ID
- AA11316464
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- ISSN
- 13475207
- 13449702
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- NDL書誌ID
- 10376450
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDLサーチ
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- CiNii Articles
- OpenAIRE
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