Oxidative stress more strongly induced by ortho‐ than para‐quinoid polycyclic aromatic hydrocarbons in A549 cells

DOI 機関リポジトリ 機関リポジトリ (HANDLE) NDLデジタルコレクション Web Site ほか1件をすべて表示 一部だけ表示 被引用文献32件 参考文献22件 オープンアクセス
  • Motoyama Yumi
    Graduate School of Natural Science and Technology, Kanazawa University
  • Bekki Kanae
    Graduate School of Natural Science and Technology, Kanazawa University
  • Chung Sang Woon
    Graduate School of Natural Science and Technology, Kanazawa University
  • Tang Ning
    Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Kameda Takayuki
    Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Toriba Akira
    Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Taguchi Keiko
    Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University
  • Hayakawa Kazuichi
    Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University

書誌事項

タイトル別名
  • Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells
公開日
2009
資源種別
journal article
DOI
  • 10.1248/jhs.55.845
公開者
公益社団法人 日本薬学会

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説明

The effect of four ortho-quinoid polycyclic aromatic hydrocarbons (PAHs) and seven para-quinoid PAHs on the viability of A549 cells were examined. The ortho-quinoid PAHs [1,2-naphthoquinone (1,2-NQ), 9,10-phenanthrenquinone (9,10-PQ), 5,6-chrysenequinone (5,6-CQ), and benzo[c]phenanthrene-5,6-quinone (B[c]P-5,6-Q)] overproduced hydrogen peroxide (H2O2) without being consumed themselves. These ortho-quinoid had strong cytotoxic effects except for 1,2-NQ, since of its tendency to covalently bind to thiol groups. The cytotoxicity appears to be due to the overproduction of H2O2 by ortho-quinoid PAHs in a redox cycle coupled with the consumption of thiol group. In contrast, the para-quinoid PAHs were not as strong cytotoxic and did not produce H2O2.

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