Proportion of Murine Cytotoxic T Cells is Increased by High Molecular-Weight Fucoidan Extracted from Okinawa mozuku (Cladosiphon okamuranus)

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  • Shimizu Jun
    Department of Clinical Dietetics & Human Nutrition, Faculty of Pharmaceutical Science, Josai University
  • Wada-Funada Urara
    Department of Clinical Dietetics & Human Nutrition, Faculty of Pharmaceutical Science, Josai University
  • Mano Hiroshi
    Department of Clinical Dietetics & Human Nutrition, Faculty of Pharmaceutical Science, Josai University
  • Matahira Yoshiharu
    Research & Developing Division, Yaizu Suisankagaku Industry Co., Ltd.
  • Kawaguchi Mitsuaki
    Research & Developing Division, Yaizu Suisankagaku Industry Co., Ltd.
  • Wada Masahiro
    Department of Clinical Dietetics & Human Nutrition, Faculty of Pharmaceutical Science, Josai University

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説明

Male BALB/c mice were administered three fucoidans with different molecular weights prepared from Okinawa mozuku (Cladosiphon okamuranus). The proportion of CD8+ cells in the spleens of mice fed with high molecular-weight fucoidan significantly increased compared with those in mice fed a control diet. In addition, the CD4+/CD8+ ratio tended to decrease and the proportion of CD11b+ cells to increase. These results suggest that high molecular-weight fucoidan promotes an increase in the proportion of murine cytotoxic T cells. <br>

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