Microbial Degradation of Disinfectants. A New Chlorhexidine Degradation Intermediate (CHDI), CHDI-C, Produced by Pseudomonas sp. Strain No. A-3

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  • Tanaka Teruo
    Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto University
  • Murayama Sawa
    Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto University
  • Tuda Natuki
    Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto University
  • Nishiyama Masami
    Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto University
  • Nakagawa Kazuko
    Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University
  • Matsuo Yasuko
    Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University
  • Isohama Youichiro
    Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University
  • Kido Yutaka
    Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto University

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  • Microbial Degradation of Disinfectants. A New Chlorhexidine Degradation Intermediate(CHDI), CHDI-C, Produced by Pseudomomas sp. Strain No.A-3

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To clarify the degradation pathway of chlorhexidine by a microbe, Pseudomonas sp. Strain No. A-3, the isolation and identification of microbial chlorhexidine degradation products were attempted. A new chlorhexidine degradation intermediate (CHDI), named CHDI-C, was isolated by extraction with ethylacetate, n-butanol, column chromatography using Silica gel, and purified by preparative thin layer chromatography. The chemical structure of this product was examined by infrared, 1H NMR, 13C NMR and fast atom bombardment mass spectra studies. Based on the spectroscopic data, this product was assumed to be a modified compound of chlorhexidine (molecular weight, MW; 530). From the proposed structure, CHDI-C was assumed to be a new chlorhexidine degradation intermediate. <br>

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