Apoptosis Induced in Human Cell Lines by a Butanol Extract from Chlorophytum comosum Roots
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- Matsushita Hirohisa
- Bioscience Research & Development Center, Nichirei Division of Organic and Bioorganic Chemistry, Kyoritsu University of Pharmacy
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- Kuwabara Hiroaki
- Division of Organic and Bioorganic Chemistry, Kyoritsu University of Pharmacy
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- Ishikawa Satoko
- Division of Organic and Bioorganic Chemistry, Kyoritsu University of Pharmacy
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- Mochizuki Masataka
- Division of Organic and Bioorganic Chemistry, Kyoritsu University of Pharmacy
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抄録
The antiproliferative effects of a n-butanol extract from Chlorophytum comosum (C. comosum) (spider plant) roots was tested in vitro against four human cell lines: HeLa, CCRF-HSB-2, HL-60 and U937 cells. The extract was found to have cell antiproliferative effects against HeLa, CCRF-HSB-2, HL-60 and U937 cell lines, with an IC50 value of 6.6, 5.4, 8.7 and 10.2 μg/ml, respectively. The dying cells showed characteristics of apoptosis, such as DNA fragmentation, as assessed by DNA electrophoresis analysis and the Terminal deoxynucleotidyl transferase (TdT)-mediated biotin dUTP Nick End-Labeling (TUNEL) method. These results indicate that extract from C. comosum roots can induce apoptosis in human cell lines. <br>
収録刊行物
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- JOURNAL OF HEALTH SCIENCE
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JOURNAL OF HEALTH SCIENCE 51 (3), 341-345, 2005
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679474740480
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- NII論文ID
- 10016657668
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- NII書誌ID
- AA11316464
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- ISSN
- 13475207
- 13449702
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- NDL書誌ID
- 7318474
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可