Liver Proteins that are Sensitive to a Dioxin-Like Toxic Compound, Coplanar Polychlorinated Biphenyl, 3,3',4,4',5-Pentachlorobiphenyl.

DOI NDLデジタルコレクション Web Site Web Site 被引用文献3件 参考文献143件 オープンアクセス
  • Ishii Yuji
    Department of Environmental Medicine, Institute of Community Medicine, University of Tsukuba
  • Oguri Kazuta
    Graduate School of Pharmaceutical Sciences, Kyushu University

書誌事項

公開日
2002
DOI
  • 10.1248/jhs.48.97
公開者
公益社団法人 日本薬学会

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説明

This review deals with the reducing ability of a dioxin-like toxic compound, coplanar polychlorinated biphenyl, 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) in protein levels of rat liver aldolase B, carbonic anhydrase III, class I alcohol dehydrogenase (ADH), glucose regulated protein 78 (GRP78), GRP94, calreticulin, and calnexin as well as the inducing ability in hepatic cytosolic 54 K protein (tentative selenium binding protein/acetaminophen binding protein homologue), heat shock protein 70 (HSP70) and HSP90. These data could provide new aspects of dioxin's toxicity via marked changes in the levels of proteins with important functions.<br>

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