Inhibitory and Killing Activities of Medicinal Plants against Multiple Antibiotic-resistant Helicobacter pylori
-
- Voravuthikunchai Supayang Piyawan
- Natural Products Research Center and Department of Microbiology, Faculty of Science, Prince of Songkla University
-
- Mitchell Hazel
- The Australian Helicobacter Reference Laboratory, School of Biotechnology and Biomolecular Sciences, The University of New South Wales
この論文をさがす
説明
Multiple antibiotic-resistant Helicobacter pylori (H. pylori), one of the major causes of gastric cancer, is now increasingly reported. The aim of this study was to screen medicinal plants widely used in Thailand as possible sources of medicines that can be used to treat H. pylori infection. Twenty-four extracts from 13 kinds of Thai herbs were tested for their antibacterial activity against 20 strains of antibiotic-resistant H. pylori. Inhibition of growth was tested by the paper disc agar diffusion method. Most strains of H. pylori examined were proved to be susceptible to seven medicinal plants; i.e., Peltophorum pterocarpum, Piper betle, Punica granatum (P. granatum), Quercus infectoria (Q. infectoria), Tamarindus indica, Uncaria gambir, and Walsura robusta. Among these extracts, P. granatum and Q. infectoria exhibited the greatest inhibitory potencies. Minimal inhibitory concentrations (MIC) were determined by the agar dilution method in Petri dishes with a Millipore filter membrane, and minimal bactericidal concentrations (MBC) were assessed with the extract that gave a significant MIC value against each bacterial strain by placing the Millipore filter membrane onto a fresh Isosensitest agar plate. Ethanolic extracts of P. granatum and Q. infectoria significantly reduced the growth of all strains of H. pylori, with the best MIC values at 0.8 and 3.1 mg/ml, and the best MBC values at 3.1 and 6.2 mg/ml, respectively. Effective fractions partially purified from both plant species yielded MICs and MBCs that were at least 10-fold less compared with the crude extracts. From the data obtained, it is hoped that P. granatum and Q. infectoria will become useful sources with which to develop new therapeutic agents for H. pylori infection.
収録刊行物
-
- JOURNAL OF HEALTH SCIENCE
-
JOURNAL OF HEALTH SCIENCE 54 (1), 81-88, 2008
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679474869760
-
- NII論文ID
- 110006570808
-
- NII書誌ID
- AA11316464
-
- ISSN
- 13475207
- 13449702
-
- NDL書誌ID
- 9351095
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDLサーチ
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可