The Biological Effects of Depolymerized Sodium Spirulan and Sulfated Colominic Acid on Vascular Cells are Beneficial in Preventing Atherosclerosis

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  • Yamamoto Chika
    Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University Organization of Frontier Research in Preventive Pharmaceutical Sciences, Hokuriku University
  • Fujiwara Yasuyuki
    Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University
  • Kaji Toshiyuki
    Department of Environmental Health, Faculty of Pharmaceutical Sciences, Hokuriku University Organization of Frontier Research in Preventive Pharmaceutical Sciences, Hokuriku University

書誌事項

タイトル別名
  • Biological Effects of Depolymerized Sodium Spirulan and Sulfated Colominic Acid on Vascular Cells are Beneficial in Preventing Atherosclerosis
公開日
2006
資源種別
journal article
DOI
  • 10.1248/jhs.52.205
公開者
公益社団法人 日本薬学会

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説明

Atherosclerosis is a vascular lesion that is a common health problem in advanced countries. Functional damage of the vascular endothelial cells, vascular smooth muscle cell hyperplasia, and procoagulant/antifibrinolytic state of blood are generally observed in the lesion. Since polysaccharides such as heparin modulate vascular cell behavior through interaction with cytokines/growth factors, we hypothesized that polysaccharides from natural sources may possess beneficial biological activities that prevent atherosclerosis. Changes in cultured aortic endothelial and smooth muscle cells were investigated after treatment with the polysaccharides sodium spirulan (Na-SP) — a sulfated polysaccharide obtained from a hot water extract of the blue-green alga Spirulina platensis — and colominic acid (CA)-prepared as a homopolymer of N-acetylneuraminic acid produced by Escherichia coli K1. The experiments suggest that depolymerized Na-SP and sulfated CA can function as precursors of the agents that prevent atherosclerosis. In particular, both the chemically modified polysaccharides significantly inhibit the proliferation of the arterial smooth muscle cells without exhibiting any toxic effects on the integrity of the vascular endothelial cell layers. The results also indicate that chemical modifications, for example, depolymerization of Na-SP and sulfation of CA, can control the biological effects of these polysaccharides on vascular cells. <br>

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