Study of 1,4-Dioxane Intake in the Total Diet

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  • Nishimura Tetsuji
    Division of Environmental Chemistry, National Institute of Health Sciences
  • Iizuka Seiichiro
    Section of Applied Testing, Japan Food Research Laboratories Osaka Branch
  • Kibune Nobuyuki
    Section of Applied Testing, Japan Food Research Laboratories Osaka Branch
  • Ando Masanori
    Division of Environmental Chemistry, National Institute of Health Sciences Faculty of Pharmacy, Research Institute of Pharmaceutical Sciences, Musashino University
  • Magara Yasumoto
    Creative Research Initiative “SOUSEI,” Graduate School of Pubulic Policy, Hokkaido University, School of Engineering, Hokkaido University

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1,4-Dioxane is a newly added compound to the water quality standards in Japan that were revised in 2003. In order to estimate the contribution of 1,4-dioxane in drinking water to the total exposure in humans, it is necessary to take into account the quantity of the compound in food. In an earlier study, we measured the intake of 1,4-dioxane in food based on the average consumption of food in the Kanto area.1) The total daily intake of 1,4-dioxane was calculated to be 0.440 μg. In the present study, we investigated the intake of 1,4-dioxane from food by sampling meals from 3 days from 3 homes in 9 prefectures, respectively. 1,4-Dioxane was extracted from 20 g of homogenates of mixed meals using the steam distillation, concentrated by a solid phase cartridge and then measured using gas-chromatography/mass spectrometry. The detection limit of the analysis was 2 μg/kg. No 1,4-dioxane was detected in 26 samples, while 3 μg/kg was detected in one sample. In this sample case, the daily intake of the 1,4-dioxane was calculated as 4.5 μg that represented 0.56% of the total daily intake (TDI) (4.5 μg/{16 μg/kg body weight/day × 50 kg}). <br>

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