Controlling Fibroblast Growth Factors for Hair Growth Regulation.

DOI
  • Suzuki Satoshi
    R & D Department of Dermatological Sciences, POLA Laboratories, POLA Chemical Industries Inc.
  • Ota Yutaka
    R & D Department of Dermatological Sciences, POLA Laboratories, POLA Chemical Industries Inc.
  • Ozawa Kazuo
    Gene Discovery Research Center, National Institute of Advanced Industrial Science and Technology (AIST)
  • Imamura Toru
    Gene Discovery Research Center, National Institute of Advanced Industrial Science and Technology (AIST)

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Other Title
  • 線維芽細胞増殖因子の調節により毛成長を促す研究

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Description

Although much research on the process of hair growth has been conducted in recent years, there is still no effective remedy for alopecia today. One reason is the lack of complete understanding of the mechanism of hair loss. Recent studies have revealed that the fibroblast growth factor-5 (Fgf-5) gene affects hair growth regulation. Moreover, it has been discovered that a short form of FGF-5 protein known as FGF-5S is produced by the Fgf-5 gene, but its effects on hair growth regulation have not been reported. We previously reported that FGF-5 and FGF-5S are located respectively in the round macrophage-like cells and hair follicles. The FGF-5-positive cells shift from dermis to panniculus adiposus during the catagen phase of the hair growth cycle, and the production of FGF-5S increases during the later half of anagen. In this study, we investigate the effects of FGF-5 and FGF-5S on the hair growth cycle. Through subcutaneous injection of FGF-5 into the dorsal region of mice, we discovered a significant inhibition of hair growth during anagen and promotion of the transition into catagen. Surprisingly, FGF-5S by itself did not affect hair growth; but when combined with FGF-5, it clearly inhibited the catagen-promoting activity of FGF-5. Our experimental results suggest that the FGF-5-positive cells shift to panniculus adiposus during catagen in order to gather around dermal papillae in which the FGF-5 receptor is expressed, and ultimately induce catagen. Clearly, FGF-5S suppresses FGF-5 activity until the onset of catagen, and alopecia is induced when the localization of the FGF-5-positive cells and/or FGF-5S production is disordered. Our results suggest the interesting possibility that by controlling and balancing the ratio of these two growth factors, a more effective preparation for treating alopecia can be developed.

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Details 詳細情報について

  • CRID
    1390282679476728704
  • NII Article ID
    130004188828
  • DOI
    10.5107/sccj.35.3_231
  • ISSN
    18844146
    03875253
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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