Ｉｎ　ｖｉｔｒｏによるアミノ酸のヒト皮膚での経皮吸収挙動の解析

DOI
  • 川崎 由明
    味の素株式会社中央研究所 カリフォルニア大学サンフランシスコ校医学部皮膚科
  • 坂本 一民
    味の素株式会社中央研究所
  • Maibach Howard I.
    Department of Dermatology, University of California Sanfrancisco

書誌事項

タイトル別名
  • Percutaneous Absorption of Amono Acids into Human Skin In Vitro.

説明

Five amino acids (L-lysine hydrochloride, glycine, sodium L-glutamate L-proline, and L-threonine) were used in this study. Their percutaneous absorption from pH 7.4 aqueous solution (PBS buffered saline) were investigated on human cadaver skin. The effects of glycerin, sodium PCA etc. on the absorption of L-proline were also investigated. Amino acids did not penetrate into the reservoir within a few hours but the amounts of adsorbed amino acid in stratum corneum were increased when glycerin or sodium PCA was incorporrated. A negative correlation between flux and log P (n-octand/water) was observed when the amino acid penetration into the receiver solution reached steady state. These resulls suggest not only the possibility of micro channels for amino acid permeation into human skin but also the possibility of incorporating amino acids into skin surface to subserve skin function.

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390282679476896128
  • NII論文ID
    130004188723
  • DOI
    10.5107/sccj.30.55
  • ISSN
    18844146
    03875253
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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