天然保湿成分であるＬ‐ピロリドンカルボン酸（Ｌ‐ＰＣＡ）のＮＯ産生調節による血流促進効果
書誌事項
- タイトル別名
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- A Natural Moisturizing Factor, L-2-Pyrrolidone-5-Carboxylic Acid (L-PCA) Enhances Blood Circulation by Modulating Constitutive NO Generation
説明
This study revealed a new physiological function of 2-pyrrolidone-5-carboxylic acid (L-PCA), which enhanced blood circulation by modulating constitutive nitric oxide (NO) generation. It is well known that NO, generated from L-arginine (L-Arg) by catalysis of NO synthase (NOS), plays a key role in the control of vascular tone and peripheral blood flow. We found a dose-dependent enhancement of constitutive NO generation by L-PCA in the human aortic endothelial cells (HAECs). In contrast, D-PCA had no influence on NO generation. Furthermore, L-PCA stimulated L-Arg uptake into HAECs dose-dependently, while D-PCA had no effect as same as NO generation. The L-Arg uptake and its stimulation by L-PCA to HAECs were suppressed with addition of L-NMMA, an inhibitor for the cationic amino acid transporter (CAT). These results indicated that enhancement of NO generation by L-PCA is due to the increase of L-Arg uptake via the CAT pathway. In conclusion, L-PCA was found to enhance blood circulation by modulating constitutive NO generation. Then we confirmed that the occlusive patch test of L-PCA to the volar forearm skin led the redness of skin, and which in turn enhanced the blood flow temporarily. This new function of L-PCA suggests development of innovative cosmetic products to care for such problematic skin as dark circles under the eyes.
収録刊行物
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- 日本化粧品技術者会誌
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日本化粧品技術者会誌 37 (4), 287-292, 2003
日本化粧品技術者会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679477094016
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- NII論文ID
- 130004188871
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- ISSN
- 18844146
- 03875253
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
