Basement Membrane Damage, a Sign of Skin Early Aging, and Laminin 5, a Key Player in Basement Membrane Care.

Amano Satoshi

doi:10.5107/sccj.35.1

Skin is composed of the epidermis and the dermis, which are separated by the epidermal basement membrane. This membrane plays an important role in maintaining the skin structure by forming anchoring complex. It also controls proliferation and differentiation of basal cells in the epidermis and maintains the polarity of the epidermis. Disruption and reduplication of the epidermal basement membrane have been reported in skin from elderly people. Indeed, they are also seen in facial skin of people in their late 20s and early 30s, when changes in skin surface texture take place. Such damage and alteration are thought to be signs of early aging of skin, which might lead to the formation of wrinkles and sagging. Therefore, early basement membrane care could be an effective approach to prevent apparent skin aging. Laminin 5 is a glycoprotein and a component of anchoring complex in the epidermal basement membrane, playing an important role in the adhesion of epidermis to dermis. Purified laminin 5 stimulates the formation of epidermal basement membrane in a skin-equivalent model and in epidermal sheet grafting in vivo. Furthermore, basement membrane formation is also enhanced by substances that stimulate laminin 5 synthesis in the skin-equivalent model, as well as by purified laminin 5. These results suggest that laminin 5 itself and substances that stimulate laminin 5 synthesis could be effective players in basement membrane care.

Basement Membrane Damage, a Sign of Skin Early Aging, and Laminin 5, a Key Player in Basement Membrane Care.

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