Protective Effects of Rose Myrtle Extract and Piceatannol against UV-induced Damage

DOI

Bibliographic Information

Other Title
  • テンニンカ果実エキスおよびその成分ピセアタンノールの紫外線ダメージ抑制作用

Abstract

Damage due to UV rays induces photoaging such as pigmentation, wrinkles and sagging in the skin. In this study, we focused on finding efficient plant extracts to prevent UV-induced damage, and found remarkable activities in Rose Myrtle (Rhodomyrtus tomentosa) extract and its key component, piceatannol. In evaluations using UVB-damaged human keratinocytes, Rose Myrtle extract and piceatannol, which have inhibitory activity on UVB-induced cell death in keratinocytes, suppressed DNA damage via a decrease of cyclobutane pyrimidine dimer levels and regulation of nucleotide excision repair gene expression. In addition, both Rose Myrtle extract and piceatannol showed anti-oxidative and anti-inflammatory activities such as an increase of glutathione synthesis, inhibition of prostaglandin E2 production and inhibition of interleukin-1β secretion. These results suggested that Rose Myrtle extract might be a useful antiaging ingredient for UV protection and piceatannol may be one of the active components of Rose Myrtle extract.

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Details 詳細情報について

  • CRID
    1390282679478173440
  • NII Article ID
    130003397154
  • DOI
    10.5107/sccj.46.17
  • COI
    1:CAS:528:DC%2BC38XntlWrsrg%3D
  • ISSN
    18844146
    03875253
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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