２官能性リジン誘導体同族列のファージ不活化活性

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  • Phage-Inactivating Activity of Homologous Series of Bifunctional Lysine Derivatives
  • 2 カンノウセイ リジン ユウドウタイ ドウゾクレツ ノ ファージ フカツカ

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A homologous series (n=2_??_15 and 18) of bifunctional lysine derivatives linked with dicarboxylic acid was synthesized and tested for phage-inactivating activity, using a wide variety of phages, to examine the influence of elongation of the methylene chain [-(CH2)n-] between two ε-amino functional groups on inactivating activity. The results indicated the longer the methylene chain, the greater the inactivating activity. For n=2_??_9, the activity showed a zigzag pattern, being greater in odd-numbered n than at the next even-numbered n. For n=10_??_18, such a zigzag pattern of activity was not observed, except in n=12_??_15 for phage δA. In the case of phage MS 2, the activity pattern was different from that of other phages. These data suggest that the longer methylene chain, along with the ε-amino group, plays an important role in phage-inactivating activity. The zigzag pattern of activity observed in the shorter chain might be due to the optimum orientation of the two ε-amino groups in interaction with target sites in the phages.

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