発泡体を担体とする固定化培養系におけるペニシリン生産特性に及ぼすＭｇ｀２´＋の添加効果

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書誌事項

タイトル別名
  • Effect of Mg2+ Addition on the Property of Penicillin Production in an Immobilized Cell Culture System Using Urethane Foams as Carrier.
  • ハッポウタイ オ タンタイ ト スル コテイカ バイヨウケイ ニ オケル ペニ
公開日
1991
DOI
  • 10.1252/kakoronbunshu.17.1048
公開者
公益社団法人 化学工学会

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説明

The effect of Mg2+ addition on penicillin production by Penicillium chrysogenum immobilized on urethane foams was investigated in a batch culture system. In the cell growth phase of the early stage of batch cultivation, the specific rates of oxygen uptake and of substrate consumption in the culture system with Mg2+ addition became lower than those in the system without Mg2+. In the last stage of the cultivation, the addition of Mg2+ could maintain specific rates of oxygen uptake and penicillin production around the maximum value. In that immobilized cell culture system, the specific rates of oxygen uptake and penicillin production changed remarkably with elasped time, and the time when these specific rates reached their maxima shifted to the later stage of cultivation by addition of Mg2+.<BR>Because such an effect of Mg2+ addition was not observed in the cell suspension culture system, it is suggested that the addition of Mg2+ was effective only in the immobilized cell culture system to keep the specific production rate of penicillin at maximum value when the concentration of lactose decreased to almost zero.

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