Optical Resolution of Imidazole Compound by Preferential Dissolution Method.
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- Nakamura Takashi
- Technological Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- Machiya Koji
- Technological Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- Kawai Nobutaka
- Technological Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- Kagara Kooji
- Technological Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
Bibliographic Information
- Other Title
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- イミダゾール体の選択的溶解法による光学分割
- イミダゾールタイ ノ センタクテキ ヨウカイホウ ニヨル コウガク ブンカツ
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Abstract
In the optical resolution of an imidazole compound by formation of salt with L-10-camphorsulfonic acid, an efficient resolution method, namely the preferential dissolution method, was established. After precipitation of both isomers' salts completely from a minimum volume of ethanol aqueous solution, an ethanol aqueous solution is added to the Crystallization Solution stepwise to dissolve preferentially the unwanted isomer. Optical purity and yield do not depend on the addition method, but on the volume of solvent and are estimated with good agreement from their solubilities. In comparison with the conventional cooling method, (+) imidazole compound is steadily obtained with higher yield (50%) and higher optical purity (97%). On the basis of these results, the method is applied to a 1700 l-crystallizer using a power number per volume as a scale up factor and good reproducibility is conformed.
Journal
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- KAGAKU KOGAKU RONBUNSHU
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KAGAKU KOGAKU RONBUNSHU 23 (5), 618-623, 1997
The Society of Chemical Engineers, Japan
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Details 詳細情報について
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- CRID
- 1390282679484532096
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- NII Article ID
- 10002767928
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- NII Book ID
- AN00037234
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- ISSN
- 13499203
- 0386216X
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- NDL BIB ID
- 4293924
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed