Biomedical Engineering. Mass Transfer Properties of Microdialysis Probe for Monitoring Glucose Level in Subcutaneous Tissues.

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  • OKOUCHI TAKAO
    Department of Materials Science and Chemical Engineering, Shizuoka University
  • OHASHI KAZUYOSHI
    Department of Materials Science and Chemical Engineering, Shizuoka University
  • KIMURA MOTOHIKO
    Department of Materials Science and Chemical Engineering, Shizuoka University
  • SUDOH MASAO
    Department of Materials Science and Chemical Engineering, Shizuoka University

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  • バイオメディカル　　皮下組織内グルコース濃度の計測のためのマイクロダイアリシス・プローブの物質移動特性
  • ヒカ ソシキナイ グルコース ノウド ノ ケイソク ノ タメ ノ マイクロ ダ

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Abstract

The purpose of this paper is to develop a microdialysis probe with higher recovery for continuous sensing of glucose concentration in subcutaneous tissue. The value for the mass transfer coefficient obtained by in vitro experiment is compared with that by in vivo experiment. Optimum conditions for fast response and high recovery are determined as a perfusion rate of 120 μl·h-1 and a probe length of 15 mm using regenareted cellulose capillary membrane. The relationship between the glucose concentration in blood and the glucose concentration in subcutaneous tissues was examined by inserting probes underneath the skin, and perfusing a dialysate of different glucose concentrations. The glucose concentration in subcutaneous tissues is found to be almostly consistent with that in blood. The mass transfer coefficient external to the probe in subcutaneous tissues, kext=1.22.4μm·s-1, is 2050% of the values of those obtained by in vitro experiments (kext=5.76.7μm·s-1).

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